HCC Part 5: Hepatocarcinogenesis: Early HCC

HCC - Proposed classification by International consensus group on HCC & WHO

EARLY HCC (VAGUELY NODULAR):

A  tumor composed of well differentiated HCC with an indistinct margin

Has following features:                       

        1. Well Differentiated                                

        2. Small size (< 2 cm)                                 

        3. Poorly marginated    (indistinct margin without tumor capsule)   

         4. Stromal invasion : Infiltration of the fibrous tissue around the portal triads or in the 

                                           surrounding tissue  (vs dysplastic nodules)                             

        4. No vascular invasion

        5. Hypovascular

        6. Almost always do not show intra-hepatic metastasis

        7. Portal tracts are retained

Prepared by Dr. Sharad Maheshwari

31.07.2023

Updated: 

References:

1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7907961/  

2. https://www.clinicalkey.in/service/content/pdf/watermarked/1-s2.0-S2352621117300244.pdf?locale=en_US&searchIndex=

3. https://pubs.rsna.org/doi/epdf/10.1148/radiol.14132361

4. https://pubmed.ncbi.nlm.nih.gov/25473149/

5. https://pubmed.ncbi.nlm.nih.gov/36010991/