Autoimmune Liver disease - general overview

on

 Autoimmune Liver disease - General overview


Three major clinico-pathological entities:


1. Autoimmune Hepatitis (AIH) - Immune related chronic liver disease

2. Primary billiary cirrhosis (PBC)

3. Primary sclerosing cholangitis (PSC)

4. Overlap syndrome: AIH with overlapping features of PSC/PBC


Histopathology 

- Plasma cell infiltrates (overlaps among the three entities)

- PBC classically has high IgM expression

- PSC and AIH have predominantly IgG expression


Biochemical:

AIH: Auto-antibodies - ANA / ASMA / anti- LKM-1 / anti-SLA

PBC: Positive AMA serology / Elevated AP

PSC: Elevated AP 


Prepared by Dr. Sharad Maheshwari

8.2.2023

Updated: 


References:

1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2811797/

2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3071169/

3. https://aasldpubs.onlinelibrary.wiley.com/doi/epdf/10.1002/hep4.1687

4. https://appliedradiology.com/communities/Pediatric-Imaging/autoimmune-hepatitis

Comments

Post a Comment