How do necrotic pancreatic collection's get infected ?

Pathophysiology of infected pancreatic necrotic collection

Peri-pancreatic necrotic collection: Initial scan vs 2 weeks follow up

Infected necrosis is a late complication of acute pancreatitis (usually occurs 2 weeks after the onset. It is considered a secondary infection.

Possible pathway:

1. Direct bacterial translocation from the gut due to decreased mucosal barrier function in the intestines,

2. Spread of microorganisms through the bloodstream into the necrotic collection from the gut or other sites

Management plan:

1. Medical management and treated as a nosocomial infection, preferably after culture

2. CT Guided intervention

3. Surgical debridement ( if no improvement 72 hours after image-guided intervention